Bee products have been used empirically for centuries especially for the treatment of respiratory diseases. Propolis can significantly reduce the number and severity of nighttime asthma attacks, improve pulmonary function and reduce inflammation (Khayyal et al., 2003). Subjects with pharyngitis treated with propolis showed a significant positive trend in symptom relief with a reduction in sore throat, fever, adenomegaly, pharyngeal erythema and exudate with the only exception in the nasal secretion that showed no
clear signs of improvement (Di Pierro et al., 2016). Propolis can be effective in relieving symptoms of allergic rhinitis by inhibiting the release of histamine (Shinmei et al., 2009). In addition, propolis is able to reduce allergic pulmonary inflammation in murine model through the involvement of lung inflammatory cells and the decrease of polymorphonuclear inflammatory cells (de Farias et al., 2014).
In particular, the antibacterial activity of M.E.D.® Propolis and it’s proved antinflammatory and antioxidant activity (Zaccaria et al., 2017; Curti et al., 2019; Zaccaria et al., 2019) suggest using the characterized polyphenol complex to treat the URTI.