Antiviral activity of different extracts of standardized propolis preparations against HSV

Sevda Demir, Ali Timucin Atayoglu, Fabio Galeotti, Emanuele U Garzarella, Vincenzo Zaccaria, Nicola Volpi, Ali Karagoz, Fikrettin Sahin

Antivir Ther. 2021, 23.

Background: Viral infections are among the most common problems in healthcare practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.®) with glycol, ethanol, glycerol, and soya oil, against herpes simplex type 1 (HSV-1) and type 2 (HSV-2) viruses.

Methods: Chemical composition and antiviral activity of each extract were determined. The selective index (SI=CC50/EC50) was determined as a parameter to indicate the in-vitro antiviral activity of the extracts compared to acyclovir as the control.

Results: SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3, and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2, and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV type 1 and type 2, while glycolic, ethanolic, and soya oil preparations were found to have more significant activity than acyclovir for HSV-2.

Conclusions: It was determined that standardized propolis preparations have antiviral bioactivity against HSV.

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