

PROPOLIS M.E.D.®
for RESPIRATORY HEALTH
- Antioxidant activity
- Antinflammatory activity
- Antibacterial activity
- Antiviral activity
Bee products have been used empirically for centuries especially for the treatment of respiratory diseases and, among them, Propolis is the most studied. B Natural has conducted extensive scientific research which led to develop a patented method of extraction (M.E.D.® extraction technology) able to standardized a polyphenol complex consistent from batch to batch and despite the carrier used. Discover more on Propolis M.E.D.® and its standardized polyphenol complex in our website..and enjoy the experience!
Scientific evidence
26 number of published articles on Propolis M.E.D.®
12 of research institutes involved in scientific research
122 patients which tested Propolis M.E.D.® for relief of URTIs symptoms
STUDIES ABSTRACTS
Upper and lower respiratory tract infections (RTIs) are common conditions which management relies on the use of prescription and over-the-counter (OTC) medicines (Hamoen et al. 2014). The clinical syndrome of URTI comprises a variety of symptoms of which cough is usually the main one and can be associated to nasal blockage/obstruction/congestion, discolored nasal discharge, fever and headache. URTIs are mainly infectious diseases resulting from interplay between microbial load (viral and bacterial) and immune response. Propolis can significantly reduce the number and severity of nighttime asthma attacks, improve pulmonary function and reduce inflammation (Khayyal et al., 2003). Subjects with pharyngitis treated with propolis showed a significant positive trend in symptom relief with a reduction in sore throat, fever, adenomegaly, pharyngeal erythema and exudate with the only exception in the nasal secretion that showed no clear signs of improvement (Di Pierro et al., 2016). Propolis can be effective in relieving symptoms of allergic rhinitis by inhibiting the release of histamine (Shinmei et al., 2009). In addition, propolis is able to reduce allergic pulmonary inflammation in murine model through the involvement of lung inflammatory cells and the decrease of polymorphonuclear inflammatory cells (de Farias et al., 2014). Recently Propolis’ M.E.D.® activity was studied by University of Naples (Italy) in a monocentric, randomized, double-blind, placebo-controlled clinical trial to investigate the relief of symptoms of uncomplicated upper respiratory tract infections (URTIs). In 2021 (publication on going) Propolis M.E.D.® has demonstrated in in-vitro tests, an interesting viral killing activity on mRNA enveloped viruses.
Features

ORGANIC

OGM FREE

ADDITIVE FREE

GLUTEN FREE

KOSHER

SUGAR FREE

LACTOSE FREE
Thanks to the patented method of extraction developed by BNatural, we are able to provide many different forms of our extracts, all with the same consistent standardized polyphenol complex, responsible for clinically proven activity.
GREIT®
hydroglyceric extract
Hydroglyceric standardized extract, obtained processing Propolis M.E.D.® mother extract with glycerin
CHARACTERISTICS
- Liquid extract
- Good taste
- Ethanol free
- Suitable for children
ADVANTAGES
- Easy to formulate in water based formulation
- Can be used without flavoring agent
- Highly stable
- No preservatives needed
APPLICATIONS
- All water based liquid formulation
TITRATION AVAILABLE
- 12 mg/mL total polyphenol complex
- 6 mg/mL total polyphenol complex
- 3 mg/mL total polyphenol complex
ESIT®
microencapsulated powder extract
Powder standardized extract, obtained through a microencapsulation process of Propolis M.E.D.® mother extract with Arabic gum
CHARACTERISTICS
- Powder extract
- Mild taste masking of propolis
- Free flowing powder
ADVANTAGES
- Easy to formulate in solid dosage forms
- Good flow and compressibility (not sticky)
- Highly stable even at high temperature (up to 180 °C)
- No preservatives needed
- Hydro-dispersible
APPLICATIONS
- All solid formulation
TITRATION AVAILABLE
- 12% total polyphenol complex expressed as Galangin
- 6% total polyphenol complex expressed as Galangin
- 3% total polyphenol complex expressed as Galangin
EPE®
hydro alcholic extract
Ethanolic standardized extract obtained processing Propolis M.E.D.® mother extract with ethanol
CHARACTERISTICS
- Liquid extract
- High propolis load
ADVANTAGES
- Easy to formulate in alcohol based formulation
- Highly stable
- No preservatives needed
- Highly customizable
APPLICATIONS
- All ethanol based liquid formulation
TITRATION AVAILABLE
- 50 mg/mL total polyphenol complex
- 38 mg/mL total polyphenol complex
- 20 mg/mL total polyphenol complex
- Many more…
POLE®
oily extract
Oily standardized extract, obtained processing Propolis M.E.D.® mother extract with vegetable oil (sunflower or soybean)
CHARACTERISTICS
- Liquid extract
- Ethanol free
- High polyphenol load
ADVANTAGES
- Ready to use for soft gels
- Highly stable
- No preservatives needed
APPLICATIONS
- Softgels
- Vaginal suppository
- Cream
TITRATION AVAILABLE
- 30 mg/mL total polyphenol complex