A recently published systematic review on propolis for oral health reported that it can reduce oral infection and dental plaque, treat stomatitis (Hwu & Lin, 2014) and herpes virus.
External uses of propolis include the use of pharmaceutical, cosmetic, and oral products such as ointment, gel, and mouthwash (Iyyam et al., 2010; Senedese et al 2010; Pereira et ak., 2011) . Propolis when used as an ingredient in mouthwashes showed protection against oral disease which is likely due to its antimicrobial efficacy (Dodwad & Kukreja, 2011). In 2012 an observational study using propolis M.E.D.® extract as ingredient in a chewingum to treat oral cavity inflammations has been performed by Clinica Dentale of Quartesolo (VI). Each of the 50 volunteers chewed chewingum contained 25 mg of ESIT 12, two applications per day. 5 days after starting of treatment the 83% reported a decrease of the symptoms linked to oral cavity inflammation; they observed also an amelioration of the aphthous (100%).
A recent study (Demir et al. 2020) showed that different estracts of standardized propolis preparation (M.E.D.) with glycol, ethanol, glycerol and soya oil, were found having potent antiviral activity against herpes simplex type 1 (HSV-virus.
A published clinical trial (Volpi et al. 2021) with Propolis M.E.D.® evaluates the activity on peridontitis compared to clorexidin performed by Italian Apitherapy Society.
Periodontitis is an extremely widespread disease, representing the sixth disease in the world by incidence. It affects 45-50% of the population and within this percentage, 10-15% has a severe form.
A significant reduction of all the considered variables was observed in the three examined groups treated with Propolis M.E.D.®, after 6 weeks.
The results of the present study are consistent with some of the previous studies. These effects are probably related to the anti-inflammatory and antibacterial effects of propolis, specifically on orange-complex bacteria.
The effectiveness of propolis in the treatment of periodontal disease is also confirmed by recent reviews with meta-analysis. The main conclusions of this analysis was that propolis is safe and can improve the periodontal disease treatment reducing probing pocket depth compared with treatment with a placebo.