The antibacterial activity of Propolis M.E.D. and it’s proved antinflammatory and antioxidant activity (Zaccaria et al., 2017, Curti et al., 2019, Zaccaria et al., 2019) suggest using the characterized polyphenol complex to treat the URTI.
In the beginning of 2019, a clinical trial began, randomized double blind placebo control study, in collaboration with University of Naples and Fatebenefratelli Hospital (Italy) to investigate activity of Propolis M.E.D. on the incidence of URTI.
In the treatment of URTI, the most common galenic forms used are: oral and nasal spray, effervescent tablets, capsules, syrups and orosoluble tablets. For these applications we suggest:
- Hydrogliceric extract GREIT for analcoholic spray, syrup etc.
- Dry extract ESIT for orosoluble tablets, effervescent tablets, capsules, candies,etc.
- Hydroalcoholic extract EPE spray, drops, etc.
All these extracts are standardized and available with different concentration of polyphenols while maintaining the characterized polyphenol complex of Propolis M.E.D.
Propolis M.E.D. is already used in medical devices thanks to its mucoadhesive properties able to promote barrier effect. Moreover, B Natural has got several formulation for oral spray in bulk, also without alcohol, ready to be packaged.